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PGRMC1 exhibits haem-dependent dimerization in solution In the PGRMC1 crystal, two different types of crystal contacts (chain A–A″ and A–B) were observed in addition to the haem-mediated dimer (chain A–A′) (Supplementary Figs 3 and 6a)

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There were in vitro and in vivo research has shown that lycopene has an important anticancer effect, which inhibited the proliferation of cancer cells through antioxidant activity, regulation of anti-inflammation, growth factor signaling, apoptosis induction, and cell arrest, such as anterior prostate cancer, cervical cancer, breast cancer, melanoma, ovarian cancer, oral cancer, hepatocellular carcinoma, lung cancer, and other cancer cells (13, 14, 80–88)